ProliCell® BaiCare: shifting the focus back to the hair follicle

In hair care, many solutions focus on the visible result: the hair itself. More shine, more density, more growth.

But there is a more important question: what is happening inside the hair follicle for that growth to occur… or stop occurring?

Today, we know that when the follicle loses activity, the hair stops responding. This calls for a change in approach: moving beyond the hair fibre itself to act at the origin of the process — the hair follicle.

In this context, ProliCell® BaiCare, developed by ACTV Biotechnology, represents a new generation of active ingredients focused on hair follicle care and function.

Unlike active ingredients such as ProliCell® Malva — which is more focused on reducing hair loss — BaiCare works directly on the condition and function of the follicle. You can learn more about Malva here.

What makes BaiCare different?

ProliCell® BaiCare is based on ProliCell® Technology, which combines plant stem cells with exosomes rich in small RNAs.

Small RNAs are fragments that help regulate gene expression, meaning they can influence how cells behave.

In this case, ACTV goes one step further: rather than simply incorporating them, small RNAs are analysed and quantified to identify those with greater relevance to hair follicle activity.

This approach enables a more precise and targeted active ingredient, designed to modulate the biological processes involved in hair growth.

What happens in the follicle when BaiCare is applied?

The efficacy of ProliCell® BaiCare is based on its ability to act on key mechanisms involved in hair follicle health:

1. Hair growth activation

Reactivates key pathways such as Wnt/β-catenin and Sonic Hedgehog, which are associated with the initiation of hair growth.

2. Regulation of the inflammatory environment

Reduces signals associated with stress and inflammation that can interfere with hair follicle activity.

3. Improved microcirculation

Supports the supply of oxygen and nutrients by stimulating processes associated with vascularisation.

4. Structural support for the follicle

Improves the viability of cells involved in hair growth, contributing to a more active and functional follicle.

Visible results with ProliCell® BaiCare

The efficacy of this approach was evaluated in studies conducted over 90 days in volunteers experiencing hair loss:

• 75% reduction in hair loss
• 6% increase in hair density
• Improved hair cycle balance, with more hair in the growth phase and less in the shedding phase
• Stronger hair with an improved overall appearance

Applications in hair care formulations

Thanks to its activity profile, ProliCell® BaiCare can be incorporated into different types of hair care products:

• Hair serums
• Scalp tonics
• Anti-hair loss shampoos
• Strengthening treatments

The active ingredient is typically used in formulations at concentrations of 2–5%.

A new approach to hair care

ProliCell® BaiCare reflects an evolution in the development of hair care active ingredients: moving from simply stimulating hair growth to creating the right conditions for the follicle to function properly.

A more comprehensive approach, focused on the origin of the process and aligned with current knowledge of hair biology.

Discover more about ProliCell® BaiCare and its applications in hair care formulations by visiting our product page or contacting our technical team.

Let’s talk!